Comparison

Digestive or systemic enzymes — which one you actually want

MitoLife sells two enzyme products with opposite instructions. Here is what each one does, why the timing differs, and how to tell which question you are asking.

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If you are looking at MitoLife’s two enzyme products and cannot tell which one you want, you have found the right question. They look similar, they are named similarly, and they do genuinely different jobs.

Here is the short answer, and then why it is the answer.

The one-line version

Digest-It-All is for the meal you are eating. Dissolve-It-All is for everything else.

That is also why one is taken around the meal and the other well away from it — and getting that backwards is the most common and most wasteful mistake in this category.

What each one actually is

Digest-It-All — 90 capsules

A blend of the enzyme classes your own digestion already uses: proteases for protein, amylase for starch, lipase for fat, plus additional enzyme extracts.

The manufacturer directs 1 or more capsules, 5 minutes before every meal, and says to adjust the amount as needed. It works in the gut, on the food that is there.

Dissolve-It-All — 90 capsules

Serrapeptase and nattokinase, two proteolytic enzymes, in an enteric capsule stated to be phthalate-free.

The manufacturer directs 1 or more capsules on an empty stomach — at least 20 minutes before a meal, or 2 hours after, with water only and not alongside food, supplements or medications.

Why the timing is opposite

This is the part worth understanding, because once you have it the choice makes itself.

A digestive enzyme is meant to act on your meal. It works in the gut, alongside what your body already produces. Take it on an empty stomach and there is simply nothing there for it to do.

A systemic enzyme is meant to be absorbed and act beyond the gut. A meal in the stomach gives it a substrate, and it gets used up on your lunch instead. The enteric coating exists for the same reason — these enzymes are proteins, stomach acid is very good at destroying proteins, and the coating is what carries them past it.

So the instructions are not preferences. They are the mechanism. Taken at the wrong time, either product stops doing the thing you bought it for.

What overlaps

Honestly, very little.

Both products contain enzymes that break peptide bonds, so at the level of chemistry there is a family resemblance. That is where it ends. Neither substitutes for the other, and buying one because you could not decide will not half-solve the other question.

What does not overlap — and this one matters

Nattokinase affects how blood clots. It has documented fibrinolytic and antiplatelet activity, and that consideration applies to Dissolve-It-All and not to Digest-It-All.

If you take an anticoagulant or antiplatelet medication, or you have surgery or a dental procedure coming up, that is a conversation with your prescriber before it is a purchase. And to be explicit about something you may read elsewhere: do not use another supplement to offset it.

Digestive enzymes carry no equivalent consideration. If that asymmetry is what decides it for you, that is a perfectly good reason to decide.

Which one suits which buyer

What each one costs to use

We are not going to give you a cost per day for these, and it is worth saying why.

Cost per capsule is straightforward — it is the bottle price divided by the capsule count, and both of those we check against the storefront. Cost per day is not. The manufacturer directs 1 or more capsules before every meal for Digest-It-All and tells you to adjust as needed, so a daily figure would need us to assume how many meals you eat and how many capsules you take with each. Those are your numbers, not ours.

What we can say plainly: Dissolve-It-All costs more per bottle, and is taken less often. How that lands for you depends on how many capsules a day you actually end up taking.

When neither is the obvious answer

Worth saying plainly, since this is a page with affiliate links on it.

If your digestion is generally fine, neither product is solving a problem you have. Enzymes are not a supplement most people need a reason to avoid — they are a supplement most people need a reason to start.

If something has changed recently — new or persistent discomfort, a change in what you can tolerate, symptoms that are getting worse rather than staying level — that is worth a proper look from a clinician rather than a capsule. Not because supplements are dangerous, but because a real answer is more useful than a partial one, and enzymes can mask a signal worth investigating.

If you are choosing between these and a cheaper single-enzyme product, that is a reasonable thing to do. The argument for a blend is convenience and coverage, not superiority.

The one number neither product gives you

Enzymes are measured in activity units — HUT and DU for proteases and amylases, SPU for serrapeptase, FU for nattokinase. Mass and enzyme activity are different measurements, so equal declared masses do not tell you the measured activity is equal. And where a figure is declared, the same activity measure, for the same enzyme, on a compatible serving basis, lets you compare that declared measurement — not the two products as wholes.

Neither product’s Supplement Facts panel declares activity units — and we should be precise about what we checked, because it is less than we would like. Both panels are published as images, and we could not read them. What we could read is what the pages link to.

Digest-It-All links no laboratory documents at all, so whether it publishes activity data anywhere is something we simply do not know. Dissolve-It-All links three, and two of them do report a protease activity figure in PC units per capsule, by a Food Chemicals Codex method. That is more than most products in this category publish. It is also lot-specific, it does not name serrapeptase or nattokinase individually, and one of the three documents carries a product name that does not match the product it is linked from — so we are not treating it as settled.

The practical upshot is unchanged. You can compare these two to each other on purpose, timing and cost per capsule — which is what this page has done — but you cannot compare either against another brand on strength from the label. If you write to the manufacturer about one thing, make it that.

Written and reviewed by CJ. Last verified 2026-09-05. Next review due 2027-03-05.